Association between Alterations of the Choriocapillaris Microcirculation and Visual Function and Cone Photoreceptors in Patients with Diabetes （糖尿病患者における脈絡膜毛細血管微小循環の変化と視機能及び錐体細胞との関連）
著者
間瀬, 智子
(Mase, Tomoko)
上位タイトル
Investigative ophthalmology and visual science
Vol.61,
No.6
(2020.
6)
,p.1-
識別番号
ISSN
0146-0404
DOI
10.1167/iovs.61.6.1.
その他
PMID: 32492109
博士論文情報
学位授与番号
10107A550
学位授与年月日
2020-09-30
学位名
博士（医学）
学位授与機関
旭川医科大学
抄録
Purpose
The purpose of this study was to investigate the association between the choriocapillaris microcirculation and the visual function and cone photoreceptor structure in patients with diabetes.
Methods
Thirteen control subjects and 26 patients with type 2 diabetes were recruited. The patients with diabetes were divided into three groups based on the grade of diabetic retinopathy (DR). The retinal sensitivity (RS) was evaluated using microperimetry. Cone photoreceptor mosaics were imaged using an adaptive optics retinal camera, and the cone heterogeneity packing index (HPi) was calculated. Optical coherence tomography angiography (OCTA) images of the choriocapillaris were obtained using spectral-domain OCTA, and the area of flow deficit (FD) was evaluated. All parameters were evaluated in the foveal and parafoveal areas.
Results
The study included four patients with diabetes without retinopathy, 12 patients with nonproliferative diabetic retinopathy (NPDR), and 10 patients with proliferative diabetic retinopathy (PDR). The foveal and parafoveal FDs were correlated significantly (fovea, r = −0.58; P = 0.046 and r = −0.82; P = 0.003; parafovea, r = −0.59; P = 0.044 and r = −0.72; and P = 0.019, respectively) with the RS in patients with NPDR and PDR, but not in control and no diabetic retinopathy (NDR) groups. There were no differences in the foveal HPi among the groups.
Conclusions
Impaired choriocapillaris microcirculation is associated with impaired visual function but not cone photoreceptor integrity in eyes with DR.
