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ID 20200930_K550
アイテムタイプ Article
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本文 K550 Mase Tomoko_ED.pdf
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タイトル Association between Alterations of the Choriocapillaris Microcirculation and Visual Function and Cone Photoreceptors in Patients with Diabetes (糖尿病患者における脈絡膜毛細血管微小循環の変化と視機能及び錐体細胞との関連)
著者
間瀬, 智子 (Mase, Tomoko)
上位タイトル
Investigative ophthalmology and visual science Vol.61, No.6  (2020. 6) ,p.1-
識別番号
ISSN
0146-0404
DOI 10.1167/iovs.61.6.1.
その他
PMID: 32492109
博士論文情報
学位授与番号 10107A550
学位授与年月日 2020-09-30
学位名 博士(医学)
学位授与機関 旭川医科大学
抄録 Purpose

The purpose of this study was to investigate the association between the choriocapillaris microcirculation and the visual function and cone photoreceptor structure in patients with diabetes.
Methods

Thirteen control subjects and 26 patients with type 2 diabetes were recruited. The patients with diabetes were divided into three groups based on the grade of diabetic retinopathy (DR). The retinal sensitivity (RS) was evaluated using microperimetry. Cone photoreceptor mosaics were imaged using an adaptive optics retinal camera, and the cone heterogeneity packing index (HPi) was calculated. Optical coherence tomography angiography (OCTA) images of the choriocapillaris were obtained using spectral-domain OCTA, and the area of flow deficit (FD) was evaluated. All parameters were evaluated in the foveal and parafoveal areas.
Results

The study included four patients with diabetes without retinopathy, 12 patients with nonproliferative diabetic retinopathy (NPDR), and 10 patients with proliferative diabetic retinopathy (PDR). The foveal and parafoveal FDs were correlated significantly (fovea, r = −0.58; P = 0.046 and r = −0.82; P = 0.003; parafovea, r = −0.59; P = 0.044 and r = −0.72; and P = 0.019, respectively) with the RS in patients with NPDR and PDR, but not in control and no diabetic retinopathy (NDR) groups. There were no differences in the foveal HPi among the groups.
Conclusions

Impaired choriocapillaris microcirculation is associated with impaired visual function but not cone photoreceptor integrity in eyes with DR.
キーワード
diabetic retinopathy
optical coherence tomography angiography
choriocapillaris
visual function
cone photoreceptors
言語
eng
資源タイプ application/pdf
ジャンル Thesis or Dissertation
著者版フラグ ETD
Index
/ Public
/ Public / 学位論文
/ Public / 学位論文 / 博士論文2020.3~
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