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閲覧数:1198
ID 20190325_O478
アイテムタイプ Article
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本文 O478 Kyuragi Rutesara_AB.pdf
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タイトル Association between obesity and acute severity among patients hospitalized for asthma exacerbation
別タイトル
気管支喘息の急性増悪による入院患者の急性期における重傷度と肥満の関連性の検討
著者
久良木, ルーテ彩来 (Kyuragi, Rutesara(Sarah Luthe))
上位タイトル
The Journal of Allergy and Clinical Immunology Vol.6, No.6  (2018. 11-12) ,p.1936- 1941
識別番号
ISSN
2213-2198
DOI 10.1016/j.jaip.2018.02.001
その他
PMID：29452277
博士論文情報
学位授与番号 10107B478
学位授与年月日 2019-3-25
学位名 博士（医学）
学位授与機関 旭川医科大学
抄録 BACKGROUND:

Although studies have demonstrated relations between obesity and incident asthma, little is known about the association of obesity with acute severity in adults hospitalized for asthma exacerbation.
OBJECTIVES:

To investigate the association of obesity with acute severity of asthma exacerbation.
METHODS:

This is a retrospective cohort study using population-based data of 8 geographically diverse US states from 2010 through 2013. We included adults (age 18-54 years) hospitalized for asthma exacerbation. The outcome measures were markers of acute severity-use of mechanical ventilation (defined by noninvasive positive pressure ventilation and/or invasive mechanical ventilation) and hospital length of stay. To determine the association of obesity with each outcome, we fit multivariable models adjusting for patient-level confounders (eg, age, sex, race/ethnicity, primary insurance, quartiles for household income, residential status, and comorbidities) and potential patient clustering within hospitals.
RESULTS:

Among the 72,086 patients hospitalized for asthma exacerbation, 24% were obese. Obesity was associated with a significantly higher risk of any mechanical ventilation use (8.3% vs 5.0%; adjusted odds ratio [OR], 1.77; 95% CI, 1.63-1.92; P < .001) driven by the higher risk of noninvasive positive pressure ventilation use (7.2% vs 3.4%; adjusted OR, 2.14; 95% CI, 1.96-2.35; P < .001). Likewise, obese patients were more likely to have a hospital length of stay of 3 or more days compared with nonobese patients (59.4% vs 46.5%; adjusted OR, 1.37; 95% CI, 1.32-1.43; P < .001). These findings were consistent with stratifications by age, sex, and race/ethnicity.
CONCLUSIONS:

In this population-based study of adults hospitalized for asthma exacerbation, obesity was associated with higher acute severity.
キーワード
Acute severity
Adults
Asthma
Hospitalization
Obesity
言語
jpn
資源タイプ application/pdf
ジャンル Thesis or Dissertation
著者版フラグ none
Index
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/ Public / 学位論文
/ Public / 学位論文 / 博士論文
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