Association of premorbid personality with behavioral and psychological symptoms in dementia with Lewy bodies: comparison with Alzheimer's disease patients
別タイトル
レビー小体型認知症における病前性格と認知症の行動・心理症状の関連：アルツハイマー型認知症と比較して
著者
田端, 一基
(Tabata, Kazuki)
上位タイトル
Psychiatry and clinical neurosciences.
Vol.71,
No.6
(2017.
6)
,p.409-
416
識別番号
ISSN
1323-1316
DOI
10.1111/pcn.12511
その他
PMID：28177178
博士論文情報
学位授与番号
10107A514
学位授与年月日
2017-06-30
学位名
博士（医学）
学位授与機関
旭川医科大学
抄録
AIM:
The aim of this study was to elucidate the relation between premorbid personality traits and behavioral and psychological symptoms in dementia (BPSD) in dementia with Lewy bodies (DLB) and Alzheimer's disease (AD) patients.
METHODS:
Forty-one DLB patients and 98 AD patients were assessed for BPSD using the Neuropsychiatric Inventory (NPI). Each patient's midlife personality traits were rated by a family member using the NEO Five-Factor Inventory (NEO-FFI) questionnaire.
RESULTS:
In multiple regression analyses for DLB patients, NPI total score and anxiety were significantly associated with premorbid openness, delusion with premorbid agreeableness, and agitation with premorbid conscientiousness. In AD patients, depression was significantly associated with premorbid neuroticism, and agitation, apathy, and irritability with premorbid agreeableness.
CONCLUSION:
Premorbid personalities affected BPSD differently in DLB and AD. Given the differences in the effects of premorbid personalities on BPSD, additional studies are needed to develop interventions to reduce these symptoms.
