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閲覧数:1023
ID 20170324_K510
アイテムタイプ Article
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本文 K510 Ogawa Hiroshi_AB.pdf
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Last updated : Apr 26, 2017
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タイトル Clinical Impact and Implication of Real-Time Oscillation Analysis for Language Mapping.
著者
小川, 博司 (Ogawa, Hiroshi)
上位タイトル
World neurosurgery No.97  (2017. 1) ,p.123- 131
識別番号
ISSN
1878-8750
DOI 10.1016/j.wneu.2016.09.071.
その他
PMID:27686506
博士論文情報
学位授与番号 10107A510
学位授与年月日 2017-03-24
学位名 博士(医学)
学位授与機関 旭川医科大学
抄録 BACKGROUND:

We developed a functional brain analysis system that enabled us to perform real-time task-related electrocorticography (ECoG) and evaluated its potential in clinical practice. We hypothesized that high gamma activity (HGA) mapping would provide better spatial and temporal resolution with high signal-to-noise ratios.
METHODS:

Seven awake craniotomy patients were evaluated. ECoG was recorded during language tasks using subdural grids, and HGA (60-170 Hz) maps were obtained in real time. The patients also underwent electrocortical stimulation (ECS) mapping to validate the suspected functional locations on HGA mapping. The results were compared and calculated to assess the sensitivity and specificity of HGA mapping. For reference, bedside HGA-ECS mapping was performed in 5 epilepsy patients.
RESULTS:

HGA mapping demonstrated functional brain areas in real time and was comparable with ECS mapping. Sensitivity and specificity for the language area were 90.1% ± 11.2% and 90.0% ± 4.2%, respectively. Most HGA-positive areas were consistent with ECS-positive regions in both groups, and there were no statistical between-group differences.
CONCLUSIONS:

Although this study included a small number of subjects, it showed real-time HGA mapping with the same setting and tasks under different conditions. This study demonstrates the clinical feasibility of real-time HGA mapping. Real-time HGA mapping enabled simple and rapid detection of language functional areas in awake craniotomy. The mapping results were highly accurate, although the mapping environment was noisy. Further studies of HGA mapping may provide the potential to elaborate complex brain functions and networks.
言語
jpn
資源タイプ application/pdf
ジャンル Thesis or Dissertation
著者版フラグ none
Index
/ Public
/ Public / 学位論文
/ Public / 学位論文 / 博士論文
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