Improved prefrontal activity in AD/HD children treated with atomoxetine: a NIRS study.
著者
荒木, 章子
(Araki, Akiko)
池上, 将永
(Ikegami, Masanaga)
岡山, 亜貴恵
(Okayama, Akie)
松本, 直也
(Matsumoto, Naoya)
高橋, 悟
(Takahashi, Satoru)
東, 寛
(Azuma, Hiroshi)
高橋, 雅治
(Takahashi, Masaharu)
上位タイトル
Brain and Development
Vol.37,
No.1
(2015.
1)
,p.76-
87
識別番号
ISSN
0387-7604
DOI
10.1016/j.braindev.2014.03.011
その他
PMID:24767548
抄録
BACKGROUND/AIMS:
Atomoxetine (ATX), a selective norepinephrine reuptake inhibitor, is the first approved non-stimulant drug for treatment of attention deficit/hyperactivity disorder (AD/HD). The present study examined the effects of long-term treatment with ATX on prefrontal hemodynamic activity in AD/HD children during a continuous performance task (CPT) using near-infrared spectroscopy (NIRS).
METHODS:
Prefrontal hemodynamic activity was measured in 12 children with AD/HD during experimental sessions conducted before and 6 months or more after starting ATX treatment. The average maintenance dose of ATX was 1.6 mg/kg/day. Fourteen age-matched typically developing children participated as a control group.
RESULTS:
In the control group, the CPT induced a significant increase in oxygenated hemoglobin (oxy-Hb) concentration in the bilateral dorsolateral prefrontal cortex (DLPFC). In the AD/HD group in the pre-ATX condition, the CPT did not induce a significant increase in oxy-Hb concentration in any of the NIRS channels, but induced a significant decrease in oxy-Hb concentration in the left ventrolateral prefrontal cortex (VLPFC). In the AD/HD group in the post-ATX condition, significant activation was observed in the right DLPFC and the decrease in oxy-Hb concentration in the left VLPFC disappeared.
CONCLUSIONS:
These results suggest that long-term treatment with ATX improved prefrontal hemodynamic activity in AD/HD children, and NIRS may be useful for assessment of the prefrontal hemodynamic response to ATX treatment.
