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閲覧数:997
ID 20160325_K495
アイテムタイプ Article
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本文 K495 Yong-Seok Song_TD.pdf
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Last updated : Apr 25, 2016
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タイトル フリッカー光刺激後の網膜血流増加反応における Glia 細胞の役割
著者
宋, 勇錫 (Song, Yong-Seok)
上位タイトル
Investigative Ophthalmology and Visual Science Vol.56, No.12  (2015. 11) ,p.7551- 7559
識別番号
ISSN
0146-0404
DOI 10.1167/iovs.15-17676
その他
PMID:26618647
博士論文情報
学位授与番号 10107A495
学位授与年月日 2016-03-25
学位名 博士（医学）
学位授与機関 旭川医科大学
抄録 PURPOSE:

To investigate how glial cells participate in retinal circulation during flicker stimulation in cats.
METHODS:

Using laser Doppler velocimetry, we measured the vessel diameter and blood velocity simultaneously and calculated the retinal blood flow (RBF) in feline first-order retinal arterioles. Twenty-four hours after intravitreal injections of L-2-aminoadipic acid (LAA), a gliotoxic compound, and the solvent of 0.01 N hydrochloric acid as a control, we examined the changes in RBF in response to 16-Hz flicker stimulation for 3 minutes. We also measured the changes in RBF 2 hours after intravitreal injection of Nω-propyl-L-arginine (L-NPA), a selective neuronal nitric oxide synthase inhibitor, in LAA-treated eyes. To evaluate the effects of LAA on retinal neuronal function, ERGs were monitored. Immunohistochemical examinations were performed.
RESULTS:

In LAA-treated eyes, histologic changes selectively occurred in retinal glial cells. There were no significant reductions in amplitude or elongation of implicit time in ERG after LAA injections compared with controls. In control eyes, the RBF gradually increased and reached the maximal level (53.5% ± 2.5% increase from baseline) after 2 to 3 minutes of flicker stimulation. In LAA-treated eyes, the increases in RBF during flicker stimulation were attenuated significantly compared with controls. In LAA-treated eyes 2 hours after injection of L-NPA, flicker-evoked increases in RBF decreased significantly compared with LAA-treated eyes.
CONCLUSIONS:

The current results suggested that increases in RBF in response to flicker stimulation were regulated partly by retinal glial cells.
言語
eng
資源タイプ application/pdf
ジャンル Thesis or Dissertation
著者版フラグ ETD
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