Role of the cannabinoid signaling in the brain orexin- and ghrelin-induced visceral antinociception in conscious rats
著者
奥村, 利勝
(Okumura, Toshikatsu)
野津, 司
(Nozu, Tsukasa)
粂井, 志麻
(Kumei, Shima)
大平, 賀子
(Ohhira, Masumi)
上位タイトル
Journal of Pharmacological Sciences
Vol.137,
No.2
(2018.
6)
,p.230-
232
識別番号
ISSN
1347-8613
DOI
10.1016/j.jphs.2018.06.001.
その他
PMID：29958814
抄録
We hypothesized that the cannabinoid (CB) system may mediate the brain orexin- or ghrelin-induced visceral antinociception. Intraperitoneal injection of either CB1/2 agonist, WIN 55212 or O-Arachidonoyl ethanolamine increased the threshold volume of colonic distension-induced abdominal withdrawal reflex in rats, suggesting CB could induce visceral antinociception. Pretreatment with either the CB1 or CB2 antagonist potently blocked the centrally injected orexin-A-induced antinociceptive action against colonic distension while CB2 but not CB1 antagonist blocked the brain ghrelin-induced visceral antinociception. These results suggest that the cannabinoid signaling may be involved in the central orexin- or ghrelin-induced antinociceptive action in a different mechanistic manner.
キーワード
Cannabinoid
Neuropeptide
Visceral sensation
注記
This is an open access article under the CC BY-NC-ND license(http://creativecommons.org/ licenses/by-nc-nd/4.0/)
