Probiotic-derived ferrichrome inhibits colon cancer progression via JNK-mediated apoptosis
著者
小西, 弘晃
(Konishi, Hiroaki)
藤谷, 幹浩
(Fujiya, Mikihiro)
田中, 宏樹
(Tanaka, Hiroki)
上野, 伸展
(Ueno, Nobuhiro)
盛一, 健太郎
(Moriichi, Kentaro)
笹嶋, 順平
(Sasajima, Junpei)
生田, 克哉
(Ikuta, Katsuya)
阿久津, 弘明
(Akutsu, Hiroaki)
田邊, 裕貴
(Tanabe, Hiroki)
高後, 裕
(Kohgo, Yutaka)
上位タイトル
Nature communications
Vol.7,
(2016.
8)
,p.1-
12
識別番号
DOI
10.1038/ncomms12365.
その他
PMID：27507542
抄録
Previous reports have suggested that some probiotics inhibit tumorigenesis and cancer progression. However, the molecules involved have not yet been identified. Here, we show that the culture supernatant of Lactobacillus casei ATCC334 has a strong tumour-suppressive effect on colon cancer cells. Using mass spectrometry, we identify ferrichrome as a tumour-suppressive molecule produced by L. casei ATCC334. The tumour-suppressive effect of ferrichrome is greater than that of cisplatin and 5-fluorouracil, and ferrichrome has less of an effect on non-cancerous intestinal cells than either of those agents. A transcriptome analysis reveals that ferrichrome treatment induces apoptosis, which is mediated by the activation of c-jun N-terminal kinase (JNK). Western blotting indicates that the induction of apoptosis by ferrichrome is reduced by the inhibition of the JNK signalling pathway. This we demonstrate that probiotic-derived ferrichrome exerts a tumour-suppressive effect via the JNK signalling pathway.
注記
This work is licensed under a Creative Commons Attribution 4.0 International License.
