Novel targets for natural killer/T-cell lymphoma immunotherapy
著者
熊井, 琢美
(Kumai, Takumi)
小林, 博也
(Kobayashi, Hiroya)
原渕, 保明
(Harabuchi, Yasuaki)
上位タイトル
Immunotherapy
Vol.8,
No.1
(2016.
1)
,p.45-
55
識別番号
ISSN
1750-743X
DOI
10.2217/imt.15.103
その他
PMID：26642249
抄録
Extranodal natural killer/T-cell lymphoma, nasal type (NKTL) is a rare but highly aggressive Epstein-Barr virus-related malignancy, which mainly occurs in nasopharyngeal and nasal/paranasal areas. In addition to its high prevalence in Asian, Central American and South American populations, its incidence rate has been gradually increasing in Western countries. The current mainstay of treatment is a combination of multiple chemotherapies and irradiation. Although chemoradiotherapy can cure NKTL, it often causes severe and fatal adverse events. Because a growing body of evidence suggests that immunotherapy is effective against hematological malignancies, this treatment could provide an alternative to chemoradiotherapy for treatment of NKTL. In this review, we focus on how recent findings could be used to develop efficient immunotherapies against NKTL.
