Collectin CL-LK is a Novel Soluble Pattern Recognition Receptor for Mycobacterium tuberculosis
著者
Anthony, Troegeler
Geanncarlo, Lugo-Villarino
Søren, Hansen
Voahangy, Rasolofo
Maiken Lumby, Henriksen
森, 健一郎
(Mori, Ken-ichiro)
大谷, 克城
(Ohtani, Katsuki)
Carine, Duval
Ingrid, Mercier
Alan, Benard
Jerome, Nigou
Denis, Hudrisier
若宮, 伸隆
(Wakamiya, Nobutaka)
Olivier, Neyrolles
上位タイトル
PLoS One
Vol.10,
No.7
(2015.
7)
,p.1-
11
識別番号
ISSN
1932-6203
DOI
10.1371/journal.pone.0132692
その他
PMID:26173080
抄録
Understanding the molecular components of immune recognition of the tuberculosis (TB) bacillus, Mycobacterium tuberculosis, can help designing novel strategies to combat TB. Here, we identify collectin CL-LK as a novel soluble C-type lectin able to bind M. tuberculosis, and characterize mycobacterial mannose-capped lipoarabinomannan as a primary ligand for CL-LK. Mice deficient in CL-K1, one of the CL-LK subunits, do not display altered susceptibility to M. tuberculosis. However, we found that the amount of CL-LK in the serum of patients with active TB is reduced, compared to that in controls, and correlates inversely to the magnitude of the immune response to the pathogen. These findings indicate that CL-LK might be of interest for future diagnostic and treatment monitoring purposes.
