Muscarinic cholinoceptor-mediated activation of JNK negatively regulates intestinal secretion in mice.
著者
Md Rafiqul Islam, Khan
Md Tariqul, Islam
Yazawa, Takashi
Hayashi, Hisayoshi
鈴木, 裕一
(Suzuki, Yuichi)
宇和田, 淳介
(Uwada, Junsuke)
Abu Syed Md, Anisuzzaman
谷口, 隆信
(Taniguchi, Takanobu)
上位タイトル
Journal of Pharmacological Sciences
Vol.127,
No.1
(2015.
1)
,p.150-
153
識別番号
ISSN
1347-8613
DOI
10.1016/j.jphs.2014.10.001.
その他
PMID:25704031
抄録
Regulation of intestinal secretion is important for body fluid homeostasis. We investigated the role of three MAP kinases (MAPKs) as negative regulators in muscarinic cholinoceptor (mAChR)-mediated intestinal secretion in mice. Electrophysiological analyses revealed that mAChR stimulation enhanced intestinal chloride secretion, which was further augmented by the inhibition of JNK but not by that of ERK or p38 with specific inhibitors SP600125, U0126 or SB203580, respectively. Immunoblot analyses in colonic mucosa showed that mAChR stimulation increased MAPKs phosphorylation that was suppressed by the specific inhibitor for each MAPK. This suggests that JNK is a major negative regulator in mAChR-induced intestinal secretion.
