Bladder function in 17β-estradiol-induced nonbacterial prostatitis model in Wister rat.
著者
松本, 成史
(Matsumoto, Seiji)
Kawai, Yuko
Oka, Michiko
Oyama, Tatsuya
Hashizume, Kazumi
和田, 直樹
(Wada, Naoki)
Hori, Junichi
玉木, 岳
(Tamaki, Gaku)
北, 雅史
(Kita, Masafumi)
Iwata, Tatsuya
柿崎, 秀宏
(Kakizaki, Hidehiro)
上位タイトル
International urology and nephrology
Vol.45,
No.3
(2013.
6)
,p.749-
754
識別番号
ISSN
0301-1623
DOI
10.1007/s11255-013-0442-y
その他
PMID 23616059
抄録
OBJECTIVES:
To investigate bladder function in a model of nonbacterial prostatitis (NBP) induced in castrated rats by 17β-estradiol injection.
METHODS:
Ten-month-old male Wistar rats were divided into two groups, sham and NBP (both N = 8). NBP was induced by castration followed by daily subcutaneous injection of 17β-estradiol for 30 days. On the 31st day after surgery, we investigated (1) voiding behavior, (2) bladder blood flow (BBF), (3) prostate and bladder weight, and proinflammatory cytokines (TNF-α and CXCL1) levels and (4) bladder contractile responses to electrical field stimulation (EFS), carbachol and KCl.
RESULTS:
(1) Voiding behavior (average micturition volume, total urine volume and number of micturitions) and (2) BBF were not significantly different between the sham and NBP groups. (3) NBP led to a significant decrease in prostatic weight and increase in proinflammatory cytokine levels in the prostate, but NBP did not cause a significant change in bladder weight or proinflammatory cytokine levels in the bladder. (4) Bladder contractile forces in response to EFS, carbachol and KCl were not significantly affected by NBP.
CONCLUSIONS:
In this rat model, NBP did not cause a significant change in the level of proinflammatory cytokines in the bladder and affect bladder function.
