Dual-time-point F-18 FDG PET/CT imaging for differentiating the lymph nodes between malignant lymphoma and benign lesions
著者
中山, 理寛
(Nakayama, Michihiro)
Okizaki, Atsutaka
Ishitoya, Shunta
Sakaguchi, Miki
Sato, Junichi
Aburano, Tamio
上位タイトル
Annals of Nuclear Medicine
Vol.27,
No.2
(2013.
2)
,p.163-
169
識別番号
ISSN
0914-7187
DOI
10.1007/s12149-012-0669-1
医中誌ID
2014010325
その他
PMID：23188388
抄録
PURPOSE: The purpose of the present study is to evaluate the clinical value of dual-time-point F-18 FDG PET/CT imaging to differentiate malignant lymphoma (ML) from benign lymph node (BLN).
MATERIALS AND METHODS: The subjects were 310 lymph nodes in 84 patients (195 ML lesions in 30 patients and 115 BLN in 54 patients associated with various etiologies.). F-18 FDG PET/CT scan was performed at 50 minutes (early scan) and at 100 minutes (delayed scan) after the injection. First, the maximum standardized uptake value (SUVmax) of each lesion at early and delayed scan was calculated. Second, we estimated the difference between early and delayed SUVmax (D-SUVmax) and the retention index (RI-SUVmax) to evaluate the change of tracers in the lesions. Furthermore, proper cut-off values of them were evaluated using by receiver operating characteristic analysis. The efficacy of each parameter was analyzed with ANOVA.
RESULTS: Delayed SUVmax and D-SUVmax in ML were significantly higher than those in BLN. Proper cut-off value in delayed SUVmax was 4.0 and in D-SUVmax was 1.0. When the proper cut-off value in D-SUVmax was applied, the D-SUVmax yielded the role of diagnosis with sensitivity of 82.6%, specificity of 65.2%, positive predictive value of 80.1% and negative predictive value of 68.8%, respectively.
CONCLUSIONS: The delayed SUVmax and D-SUVmax were useful indices to differentiate ML from BLN, regardless of histologic subtype. Dual-time-point F-18 FDG PET/CT imaging may help to consider whether there is any need to proceed to more invasive tests, such as biopsy, in individual patients.
