Biological functions of the novel collectins CL-L1, CL-K1, and CL-P1.
著者
大谷, 克城
(Ohtani, Katsuki)
鈴木, 定彦
(Suzuki, Yasuhiko)
若宮, 伸隆
(Wakamiya, Nobutaka)
上位タイトル
Journal of Biomedicine and Biotechnology
No.2012
(2012.
4)
,p.1-
8
識別番号
ISSN
1110-7243
DOI
10.1155/2012/493945
その他
PMID:22570530
抄録
Collectins are characterized by a collagen-like sequence and a carbohydrate recognition domain and are members of the vertebrate C-type lectin superfamily. Recently, "novel collectins", different from "classical collectins" consisting of mannan-binding lectin (MBL) and surfactant proteins A and D (SP-A and SP-D), have been found by reverse genetics. These "novel collectins" consist of collectin liver 1 (CL-L1), collectin kidney 1 (CL-K1), and collectin placenta 1 (CL-P1) and are encoded by three separate genes. Experimental findings on human and animal collectins have shown that both novel collectins and classical collectins play an important role in innate immunity. Based on our recent results and those of others, in this paper, we summarize the new biological functions of these novel collectins in embryonic morphogenesis and development.
