Severe hyponatremia in association with I(131) therapy in a patient with metastatic thyroid cancer
著者
野津, 司
(Nozu, Tsukasa)
Yoshida, Yuri
Ohhira, Masumi
奥村, 利勝
(Okumura, Toshikatsu)
上位タイトル
Internal Medicine
Vol.50,
No.19
(2011.
)
,p.2169-
2174
識別番号
ISSN
0918-2918
その他
PMID:21963736
抄録
Hyponatremia is a common clinical problem that results from various causes. Hypothyroidism is known to be one of the causes of this disorder. We report a case of metastatic thyroid cancer presenting with severe hyponatremia in association with hypothyroidism induced by pretreatment of I(131) therapy, such as a low-iodine diet and withdrawal of thyroid hormone. Serum arginine vasopressin (AVP) was elevated and urine osmolality was higher than that of serum. Saline infusion and thyroid hormone replacement normalized serum sodium and AVP. Inappropriate secretion of AVP in hypothyroid state was thought to be one of the causes of this hyponatremia.
