Prognostic significance of overexpression of c-Met oncoprotein in cholangiocarcinoma
著者
宮本, 正之
(Miyamoto, Masashi)
Ojima, H.
Iwasaki, M.
Shimizu, H.
Kokubu, A.
Hiraoka, N.
Kosuge, T.
Yoshikawa, D.
Kono, T.
Furukawa, H.
Shibata, T.
上位タイトル
British Journal of Cancer
Vol.105,
No.1
(2011.
6)
,p.131-
138
識別番号
ISSN
0007-0920
DOI
10.1038/bjc.2011.199
抄録
Background:Cholangiocarcinoma (CC) is a highly malignant carcinoma. We attempted to clarify the prognostic significance of c-Met overexpression and its association with clinicopathological factors in patients with CC. Patients and methods:One hundred and eleven patients with intrahepatic CC (IHCC) and 136 patients with extrahepatic CC (EHCC) who had undergone curative surgery were divided immunohistologically into c-Methigh and c-Metlow groups. Clinicopathological factors and outcomes were compared between the groups. C-Met and epidermal growth factor receptor (EGFR) expression was also examined in 10 CC cell lines. Results:The positivity of c-Met was 45.0% in IHCC and 68.4% in EHCC; c-Methigh expression was demonstrated in 11.7% of IHCC and 16.2% of EHCC. C-Methigh expression was significantly correlated with the 5-year survival rate for CC overall (P=0.0046) and for IHCC (P=0.0013), histopathological classification in EHCC, and for EGFR overexpression in both IHCC and EHCC. Coexpression and coactivation of c-Met and EGFR were also observed in CC cell lines. Multivariate analysis revealed that c-Methigh expression was an independent predictor of poor overall and disease-free survival in patients with IHCC. Conclusions:c-Met overexpression is associated with EGFR expression and is a poor prognostic factor in CC.
