Clinicopathological Study of Neuroendocrine Carcinoma of the Breast
著者
北田, 正博
(Kitada, Masahiro)
安田, 俊輔
(Yasuda, Shunsuke)
阿部, 昌宏
(Abe, Masahiro)
髙橋, 奈七
(Takahashi, Nana)
岡崎, 智
(Okazaki, Satoshi)
石橋, 圭
(Ishibashi, Kei)
林, 諭
(Hayashi, Satoshi)
上位タイトル
Journal of Cancer Therapy
Vol.8,
No.8
(2017.
8)
,p.793-
799
識別番号
ISSN
2151-1934
DOI
10.4236/jct.2017.88069
抄録
Introduction: Neuroendocrine carcinoma (NEC) occurs mostly in the digestive organs, such as the pancreas and gastrointestinal tract, and the lungs. Primary NEC of the breast is a rare entity. There are not many studies on this disease, and this study was carried out in order to know the clinical pathology of this disease. Methods: Of 2354 patients who underwent surgery for breast cancer in our hospital during the period from January 2000 to July 2015, 8 (0.34%) were pathologically diagnosed with NEC of the breast. This study is retrospectively registered. Result: The histological types were small cell carcinoma in one patient and invasive ductal carcinoma (IDC) with neuroendocrine differentiation in the remaining 7. The mean patient age was slightly higher than that of patients with usual IDC. On pathological examination, the NEC tumors were more hormone dependent and often HER2 negative, as compared to usual IDC, though there was no significant difference in nuclear grade. The patients with NEC of the breast showed positivity for neuroendocrine markers on immunohistological staining, and had favorable outcomes. Conclusion: NEC of the breast is rare, and there is no established consensus regarding the pathological significance, prognosis, and treatment method. Further accumulation of cases is necessary.
キーワード
Breast Cancer
Neuroendocrine Carcinoma
注記
This work is licensed under the Creative Commons Attribution International License (CC BY 4.0)
