Plasma MIP-1α level was elevated after Con A injection. The elevated plasma ALT level, mortality rate and histological change after Con A injection were inhibited by anti-MIP-1α antibody pretreatment. The elevated plasma ALT level after Con A injection was further enhanced by recombinant murine-MIP-1α. The elevated plasma TNF-α and IFN-γ levels after Con A injection were inhibited by anti-MIP-1α antibody, and enhanced by recombinant murine-MIP-1α. GdCl_3 pretreatment inhibited the elevated plasma MIP-1α and ALT levels.
