Involvement of corneodesmosome degradation and lamellar granule transportation in the desquamation process
著者
山本, 明美
(Ishida-Yamamoto, Akemi)
Kishibe, Mari
上位タイトル
Medical Molecular Morphology
Vol.44,
No.1
(2011.
3)
,p.1-
6
識別番号
ISSN
1860-1480
DOI
10.1007/s00795-010-0513-4
抄録
Desquamation in mammalian skin is a well balanced process of producing corneocytes and shedding them from the surface of the skin. The corneodesmosome, which is a modified desmosome, is the main adhesive structure in the cornified cell layer. The major extracellular constituents of corneodesmosomes are desmoglein 1, desmocollin 1 and corneodesmosin. Proteases involved in the degradation of corneodesmosomes and their inhibitors are secreted from lamellar granules in the granular cell layer. Genetic defects in corneodesmosin and protease inhibitors result in accelerated desquamation and severe barrier impairment. Abnormalities in transportation and secretion of lamellar granules underlie ichthyosis seen in certain human diseases.
