A Newly Estimated Glomerular Filtration Rate Is Independently Associated with Arterial Stiffness in Japanese Patients (新たに提案された推定糸球体濾過値は日本人患者の動脈硬度と独立に関連する)
著者
中川, 直樹
(Nakagawa, Naoki)
Takahashi, Fumihiko
Chinda, Junko
Kobayashi, Motoi
Hayashi, Yoshikazu
Abe, Masahiko
Saijo, Yasuaki
Kikuchi, Kenjiro
Hasebe, Naoyuki
上位タイトル
Hypertension Research
Vol.31,
No.2
(2008.
2)
,p.193-
201
識別番号
ISSN
0916-9636
抄録
Chronic kidney disease (CKD) is associated with an increased risk of cardiovascular disease, and thus is a major worldwide public health problem. Recently, an estimated glomerular filtration rate (eGFR) using the Modification of Diet in Renal Disease equation for Japanese patients was proposed by the Japanese Society of Nephrology. However, the role of eGFR in the assessment of atherosclerosis is not well understood in Japanese patients. We analyzed the relationship between eGFR and severity of arterial stiffness using brachial-ankle pulse wave velocity (baPWV) in 647 adult Japanese patients. baPWV correlated significantly and positively with age, hypertension, diabetes, prior cardiovascular disease, blood pressure, pulse pressure and heart rate, and negatively with eGFR (r=-0.405, p<0.0001). A multiple regression analysis revealed that baPWV correlated independently with eGFR. Furthermore, there was a stepwise increase in baPWV, corresponding to advances in CKD through stages 1 to 5. When CKD stage 3 was divided at eGFR 45 mL/min/1.73 m2, the baPWV of stage 3b (eGFR 30 to 44) was significantly higher than that of stage 3a (eGFR 45 to 59) independent of traditional risk factors, suggesting that an eGFR of 45 mL/min/1.73 m2 may be a critical cut off value to predict arterial stiffness in CKD. In conclusion, the newly proposed eGFR is significantly associated with arterial stiffness, independent of traditional risk factors for cardiovascular disease.
(最近、日本人患者用糸球濾過値推定式が新たに提案された。本研究では新しい方法で求めた推定糸球体濾過値(eGFR)と上腕足首脈波速度によって評価した動脈硬度との関係を成人日本人647例を対象に検討した。上腕足首脈波速度は年齢、高血圧、糖尿病、心血管疾患の既往、血圧、脈圧、心拍数と有意の正相関、eGFRと有意の逆相関(r=-0.405、p<0.001)があった。多変量解析によるとeGFRとは独立した関係があった。)
