Combination of Antihypertensive Therapy in The Elderly, Multicenter Investigation (CAMUI) Trial
著者
佐藤, 伸之
(Sato, Nobuyuki)
Saijo, Yasuaki
Hasebe, Naoyuki
上位タイトル
International Heart Journal
Vol.53,
No.4
(2012.
8)
,p.244-
248
識別番号
ISSN
1349-2365
抄録
Angiotensin receptor blockers (ARBs) with calcium channel blockers (CCBs) or diuretics are a widely used combination therapy for hypertensive patients. The present study aimed to determine which combination was better for elderly hypertension patients aged ≧ 65 years.
We designed a multicentre, randomized, open-label, parallel comparison study. Hypertensive outpatients aged ≧ 65 years who did not achieve the target blood pressure (BP < 140/90 mmHg) with usual dosages of ARBs were randomly assigned to switch treatment to losartan 50 mg/hydrochlorothiazide 12.5 mg or amlodipine 5 mg in addition to ARBs. The primary endpoint was a change in the systolic blood pressure (SBP) and diastolic blood pressure (DBP) after the 3-month treatment period, while secondary endpoints were changes in the BP, albuminuria, laboratory values, and cognitive function with the mini-mental state examination (MMSE) at baseline and after one year. The results from the CAMUI trial should provide new evidence for selecting optimal combination therapies for elderly hypertensive patients.
キーワード
Antihypertensive agents、Combination therapy、Cognitive function
