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AMCoR:Asahikawa Medical University Collection and Research (旭川医科大学学術成果リポジトリ)は、本学で生産された電子的な知的生産物(学術雑誌論文の原稿・教材・学術資料など)を保存し、原則的に無償で発信するためのインターネット上の保管庫です。

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閲覧数:789
ID 28441937
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タイトル Observation of Zn-photoprotoporphyrin red Autofluorescence in human bronchial cancer using color-fluorescence endoscopy
著者
大崎, 能伸 (Ohsaki, Yoshinobu)
佐々木, 高明 (Sasaki, Takaaki)
遠藤, 哲史 (Endo, Satoshi)
北田, 正博 (Kitada, Masahiro)
奥村, 俊介 (Okumura, Shunsuke)
平井, 理子 (Hirai, Noriko)
風林, 佳大 (Kazebayashi, Yoshihiro)
豊嶋, 恵理 (Toyoshima, Eri)
山本, 泰司 (Yamamoto, Yasushi)
竹山, 周良 (Takeyama, Kaneyoshi)
中島, 進 (Nakajima, Susumu)
阪田, 功 (Sakata, Isao)
上位タイトル
BMC Cancer Vol.17, No.1  (2017. 4) ,p.289-
識別番号
ISSN
1471-2407
DOI 10.1186/s12885-017-3277-6
その他
PMID:28441937
抄録 BACKGROUND:

We observed red autofluorescence emanating from bronchial cancer lesions using a sensitive color-fluorescence endoscopy system. We investigated to clarify the origin of the red autofluorescence.
METHODS:

The wavelengths of the red autofluorescence emanating from lesions were measured in eight patients using a spectrum analyzer and compared based on pathologic findings. Red autofluorescence at 617.3, 617.4, 619.0, and 617.1 nm was emitted by normal bronchus, inflamed tissue, tissue exhibiting mild dysplasia, and malignant lesions, respectively. Protoporphyrin, uroporphyrin, and coproporphyrin, the major porphyrin derivatives in human blood, were purchased to determine which porphyrin derivative is the source of red fluorescence when acquired de novo. We synthesized photoporphyrin, Zn-protoporphyrin and Zn-photoprotoporphyrin from protoporphyrin.
RESULTS:

Coproporphyrin and uroporphyrin emitted only weak fluorescence. Fluorescence was emitted by our synthesized Zn-photoprotoporphyrin at 625.5 nm and by photoprotoporphyrin at 664.0 nm.
CONCLUSIONS:

From these results, we conclude that Zn-photoprotoporphyrin was the source of the red autofluorescence observed in bronchial lesions. Zn-protoporphyrin is converted to Zn-photoprotoporphyrin by radiation with excitation light. Our results suggest that red autofluorescence emanating from Zn-photoprotoporphyrin in human tissues could interfere with photodynamic diagnosis using porphyrin derivatives such as Photofrin® and Lazerphyrin® with a sensitive endoscopy system, because color cameras cannot differentiate Zn-photoprotoporphyrin red fluorescence from that of other porphyrin derivatives.
キーワード
Autofluorescence
Endoscopy
Photodynamic diagnosis
Prophyrin
Zn-photoprotoporphyrin
言語
eng
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