AMCoR Asahikawa Medical College
HOME
|

AMCoR:Asahikawa Medical University Collection and Research (旭川医科大学学術成果リポジトリ)は、本学で生産された電子的な知的生産物(学術雑誌論文の原稿・教材・学術資料など)を保存し、原則的に無償で発信するためのインターネット上の保管庫です。

※AMCoRに収録された学術論文のほとんどは、商業出版社や学会出版社の学術雑誌に掲載されたものですが、著作権に係わる出版社の方針により、出版社の条件に添った版を収録しています。そのため実際の誌面とはレイアウトの相違や、字句校正による文言の違いがあり得ますことをあらかじめご了承ください。


| ホーム ニュース ログイン |

Language

AMCoR検索
  
     詳細検索

インデックスツリー

詳細



閲覧数:1159
ID 28440889
アイテムタイプ Article
このアイテムを表示する
本文 28440889.pdf
Type : application/pdf Download
Size : 1.3 MB
Last updated : May 19, 2017
Downloads : 968

Total downloads since May 19, 2017 : 968
タイトル A glucagon-like peptide-1 analog, liraglutide improves visceral sensation and gut permeability in rats
著者
野津, 司 (Nozu, Tsukasa)
宮岸, 沙織 (Miyagishi, Saori)
粂井, 志麻 (Kumei, Shima)
野津, 麟太郎 (Nozu, Rintaro)
高草木, 薫 (Takakusaki, Kaoru)
奥村, 利勝 (Okumura, Toshikatsu)
上位タイトル
Journal of gastroenterology and hepatology (2017. 4)
識別番号
ISSN
0815-9319
DOI 10.1111/jgh.13808
URI http://dx.doi.org/10.1111/jgh.13808
その他
PMID:28440889
抄録 BACKGROUND AND AIM:

A glucagon-like peptide-1 (GLP-1) analog, liraglutide, has been reported to block inflammatory somatic pain. We hypothesized that liraglutide attenuates lipopolysaccharide (LPS)- and repeated water avoidance stress (WAS)-induced visceral hypersensitivity and tested the hypothesis in rats.
METHODS:

The threshold of the visceromotor response (VMR) induced by colonic balloon distention was measured to assess visceral sensation. Colonic permeability was determined in vivo by quantifying the absorbed Evans blue spectrophotometrically, which was instilled in the proximal colon for 15 min. The interleukin-6 (IL-6) level in colonic mucosa was also quantified using ELISA.
RESULTS:

Subcutaneously (s.c.) injected LPS (1 mg/kg) reduced the VMR threshold after 3 h. Liraglutide (300 µg/kg s.c.) at 15 h and 30 min before injecting LPS eliminated LPS-induced allodynia. It also blocked the allodynia induced by repeated WAS for 1 h for 3 consecutive days. Neither vagotomy nor naloxone altered the antinociceptive effect of liraglutide, but NG -nitro-L-arginine methyl ester, a nitric oxide (NO) synthesis inhibitor, blocked it. LPS increased colonic permeability and the IL-6 level, and the analog significantly inhibited these responses.
CONCLUSIONS:

This study suggests that liraglutide blocked LPS-induced visceral allodynia, which may be a NO-dependent response, and was probably mediated by inhibiting proinflammatory cytokine production and attenuating the increased gut permeability. Because the LPS-cytokine system is considered to contribute to altered visceral sensation in irritable bowel syndrome, these results indicate the possibility that liraglutide can be useful for treating this disease.
キーワード
Colonic permeability
Liraglutide
Visceral pain
Water avoidance stress
lipopolysaccharide
注記 Epub2017.4.25
言語
eng
資源タイプ text
ジャンル Journal Article
著者版フラグ author
Index
/ Public
/ Public / 国外雑誌論文
関連アイテム