Functional implications of the Golgi and microtubular network in gonadotropes.
著者
渡部, 剛
(Watanabe, Tsuyoshi)
暮地本, 宙己
(Bochimoto, Hiroki)
Koga, Daisuke
Hosaka, Masahiro
牛木, 辰男
(Ushiki, Tatsuo)
上位タイトル
Molecular and Cellular Endocrinology
Vol.385,
No.1-2
(2014.
3)
,p.88-
96
識別番号
ISSN
0303-7207
DOI
10.1016/j.mce.2013.10.003.
その他
PMID:24121198
抄録
In contrast to the widely accepted images of the Golgi apparatus as a cup-like shape, the Golgi in pituitary gonadotropes is organized as a spherical shape in which the outer and inner faces are cis- and trans-Golgi elements, respectively. At the center of the spherical Golgi, a pair of centrioles is situated as a microtubule-organizing center from which radiating microtubules isotropically extend toward the cell periphery. This review focuses on the significance of the characteristic organization of the Golgi and microtubule network in gonadotropes, considering the roles of microtubule-dependent membrane transport in the formation and maintenance of the Golgi structure. Because the highly symmetrical organization of the Golgi is possibly perturbed in response to experimental treatments of gonadotropes, monitoring of the Golgi structure in gonadotropes under various experimental conditions will be a novel in vivo approach to elucidate the biogenesis of the Golgi apparatus.
