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AMCoR:Asahikawa Medical University Collection and Research (旭川医科大学学術成果リポジトリ)は、本学で生産された電子的な知的生産物(学術雑誌論文の原稿・教材・学術資料など)を保存し、原則的に無償で発信するためのインターネット上の保管庫です。

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閲覧数:1503
ID 21441843
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タイトル Localization of the Most Severely Dysplastic/Invasive Lesions and Mucin Phenotypes in Intraductal Papillary Mucinous Neoplasm of the Pancreas
著者
唐崎, 秀則 (Karasaki, Hidenori)
Mizukami, Yusuke
Tokusashi, Yoshihiko
Koizumi, Kazuya
Ishizaki, Akira
Imai, Kouji
Yoshikawa, Daitaro
Kino, Shuichi
Sasajima, Junpei
Tanno, Satoshi
Matsumoto, Kakuya
Miyokawa, Naoyuki
Kono, Toru
Kohgo, Yutaka
Furukawa, Hiroyuki
日付
出版年:  - 
作成日: 2012-05-30
更新日: 2012-05-30
記録日
上位タイトル
Pancreas Vol.40, No.4  (2011. 5) ,p.588- 594
識別番号
ISSN
0885-3177
DOI 10.1097/MPA.0b013e31820d1a03
URI http://journals.lww.com/pancreasjournal/pages/default.aspx
http://www.ncbi.nlm.nih.gov/pubmed/21441843
抄録 Objective: The aim of this study was to define the relevance of mural nodules (MNs) as a "direct" indicator of malignancy of intraductal papillary mucinous neoplasm (IPMN) of the pancreas. Methods: Thirty-nine surgically resected IPMNs excluding obviously invasive carcinomas were examined. The distribution of the most severely dysplastic lesions was mapped on specimens. Immunohistochemical analysis for MUC1 and MUC2 was performed on sections containing the histologically predominant lesions and the most severely dysplastic areas. Results: The presence of MNs correlated well with the histological grade of IPMN (P < 0.01); however, the most severely dysplastic lesions were associated with a flat/nonelevated area rather than MNs (78.9%). In the MUC1-positive subgroup, minimally invasive carcinoma was colocalized to MNs, whereas most severely dysplastic foci including minimally invasive carcinoma with components of mucinous and tubular adenocarcinoma were observed in the areas apart from MNs in the MUC2-positive and MUC1/2-negative subgroups, respectively. Conclusions: Although our data support the concept that MNs represent areas of higher-grade dysplasia within IPMN, development of invasive lesions from MNs may be limited to cases that are MUC1-positive. Careful attention should be paid to the emergence of invasive IPMN from flat foci in MUC2-positive and MUC1/2-negative cases.
注記 This is a non-final version of an article published in final form in Karasaki, Hidenori ; Mizukami, Yusuke ; Tokusashi, Yoshihiko ; Koizumi, Kazuya ; Ishizaki, Akira ; Imai, Kouji ; Yoshikawa, Daitaro ; Kino, Shuichi ; Sasajima, Junpei ; Tanno, Satoshi ; Matsumoto, Kakuya ; Miyokawa, Naoyuki ; Kono, Toru ; Kohgo, Yutaka ; Furukawa, Hiroyuki, Pancreas, 40(4), 588-594.
言語
eng
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ジャンル Journal Article
著者版フラグ author
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