Indirect imaging of branch retinal vein occlusion using a scanning laser ophthalmoscope （走査レーザー検眼鏡を用いた網膜静脈分枝閉塞症の間接的画像化）
著者
石子, 智士
(Ishiko, Satoshi)
Yoshida, Akitoshi
Sato, Eiichi
Kato, Yuji
Nagaoka, Taiji
Frans, Van de Velde
上位タイトル
Japanese Journal of Ophthalmology
Vol.55,
No.3
(2011.
5)
,p.307-
309
識別番号
ISSN
0021-5155
抄録
Background In patients who have macular edema secondary to retinal vein occlusion, the role of vasoactive molecules such as growth factors and the influence of molecules related to leukocyte adhesion need to be investigated further.
Methods A prospective study was performed to investigate the relations between perifoveal capillary blood flow velocity and the vitreous levels of vascular endothelial growth factor (VEGF) and soluble intercellular adhesion molecule-1 (sICAM-1) in patients with macular edema and retinal vein occlusion. Undiluted vitreous specimens were obtained from 11 eyes of 11 patients with macular edema (nine had branch retinal vein occlusion and two had central retinal vein occlusion). VEGF and sICAM-1 levels were measured by enzyme-linked immunoabsorbent assay. Before vitreous sampling, perifoveal capillary blood flow velocity was measured by fluorescein angiography with a scanning laser ophthalmoscope and the tracing method. The relations between perifoveal capillary blood flow velocity and the vitreous levels of VEGF and sICAM-1 were investigated.
Results There was a significant correlation between perifoveal capillary blood flow velocity and the vitreous level of sICAM-1 (ρ=−0.7303, p=0.03). In contrast, there was no significant association between blood flow velocity and the vitreous level of VEGF (ρ=−0.1458, p=0.67).
Conclusions The vitreous level of sICAM-1 is associated with perifoveal capillary blood flow velocity in patients who have retinal vein occlusion and macular edema.
