Anti-Influenza A Virus Activities of Mannan-Binding Lectins and Bovine Conglutinin
著者
河合, 高生
(Kawai, Takao)
加瀬, 哲男
(Kase, Tetsuo)
鈴木, 定彦
(Suzuki, Yasuhiko)
江田, 宗司
(Eda, Souji)
坂本, 隆志
(Sakamoto, Takashi)
大谷, 克城
(Ohtani, Katsuki)
若宮, 伸隆
(Wakamiya, Nobutaka)
上位タイトル
Journal of Veterinary Medical Science
Vol.69,
No.2
(2007.
2)
,p.221-
224
識別番号
ISSN
0916-7250
DOI
10.1292/jvms.69.221
その他
PMID:17339771
抄録
Mannan-binding lectin (MBL) and bovine conglutinin (BKg) belong to the collectin family, which is involved in first-line host defense against various infectious agents. We have previously reported that human MBL inhibited type A influenza viral hemagglutination, infection and spreading to adjacent cells without complement activation. In this study, we investigated the direct antiviral activities of bovine MBL, rabbit MBL and BKg. All collectins used in this study inhibited viral infectivity and hemagglutination at concentrations of 0.02-0.3 μg/ml. They also demonstrated inhibitory activity against viral spreading. Like human MBL, bovine MBL and BKg showed antiviral activities at their physiological concentrations. These results suggest that mammalian MBLs and BKg may inhibit the spread of influenza A virus through the bloodstream.
