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AMCoR:Asahikawa Medical University Collection and Research (旭川医科大学学術成果リポジトリ)は、本学で生産された電子的な知的生産物(学術雑誌論文の原稿・教材・学術資料など)を保存し、原則的に無償で発信するためのインターネット上の保管庫です。

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閲覧数:3652
ID 12586603
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タイトル Inhibition of TNF-α-induced RANTES expression in human hepatocyte-derived cells by fibrates, the hypolipidemic drugs
著者
平野, 史倫 (Hirano, Fuminori)
Kobayashi, A
Makino, I
上位タイトル
INTERNATIONAL IMMUNOPHARMACOLOGY Vol.3, No.2  (2003. 2) ,p.225- 232
識別番号
ISSN
1567-5769
DOI 10.1016/S1567-5769(02)00275-8
URI http://www.sciencedirect.com/science/journal/15675769
抄録 Increased concentrations and activity of plasma cytokines produced by monocytes, macrophages, and hepatocytes in patients with alcoholic liver diseases, correlate with the clinical course of liver diseases and are of prognostic value. Especially, high levels of circulating tumor necrosis factor (TNF)-α have been found to correlate with increased mortality in alcoholic hepatitis. Moreover, hepatic RANTES was increased in patients with alcoholic hepatitis. Thus, TNF-α-induced RANTES expression may have a critical role in cell-mediated liver injury associated with alcoholic hepatitis. Fibrates are widely used in the treatment of hyperlipidemia and lower triglyceride levels in patients with hyperlipidemia. Recently, several groups reported that bezafibrate, one of fibrates, is effective in primary biliary cirrhosis treatment. Additionally, it is reported that bezafibrate is effective in the treatment not only of primary biliary cirrhosis but also of chronic hepatitis C and tamoxifen-induced non-alcoholic steatohepatitis. We, here, presented that bezafibrate and fenofibrate repressed TNF-α-induced protein production and mRNA expression of RANTES in human hepatocyte-derived cells. Luciferase assay showed that bezafibrate and fenofibrate inhibited RANTES gene expression in response to TNF-α. Moreover, bezafibrate repressed TNF-α-induced DNA-binding activity of NF-kB. Thus, fibrates reduced TNF-α-induced NF-kB activation and RANTES expression, possibly suggesting that fibrates might be inhibitory agents of migration of inflammatory cells by RANTES to the liver in patients with alcoholic liver diseases. In line of these results, it might be possible that fibrates are therapeutic agents in alcoholic liver diseases.
注記 ELSEVIER, Hirano, F; Kobayashi, A; Makino, I, INTERNATIONAL IMMUNOPHARMACOLOGY, 3(2), 225-232, 2003.

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